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Episode 54, “Making Sense of Hierarchical Composites”
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In this episode of "In the Interim…", Dr. Scott Berry is joined by statisticians Dr. Amy Crawford, Dr. Cora Allen-Savietta, and Dr. Jessica Overbey for a technical deep dive into hierarchical composite endpoints and the win ratio in clinical trial design.
Episode 54 of "In the Interim…" is now available. Dr. Scott Berry sits down with Dr. Amy Crawford, Dr. Cora Allen-Savietta, and Dr. Jessica Overbey to dissect hierarchical composite endpoints and using win ratios in clinical trials.
Key topics covered:
● The mechanics of the win ratio tests and hierarchical composites
● Power calculations and adaptive design challenges
● Observations on regulatory perspectives from FDA and EMA
● The problem of "immature win ratios" in interim analyses
Our team explores both the benefits and limitations of these methods, offering practical insights for biostatisticians designing trials with hierarchical composite endpoints.
Listen now: https://www.berryconsultants.com/resource/54-making-sense-of-hierarchical-composites
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Episode 54, “Making Sense of Hierarchical Composites”
In this episode of "In the Interim…", Dr. Scott Berry is joined by statisticians Dr. Amy Crawford, Dr. Cora Allen-Savietta, and Dr. Jessica Overbey for a technical deep dive into hierarchical composite endpoints and the win ratio in clinical trial design.
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International Society for Biopharmaceutical Statistics Symposium March 6th-9th
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PSI 2023 Conference June 11-June 14
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Advanced Statistical Methods to Borrow External Information
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Adaptive Designs and Multiple Testing Procedures Workshop
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