Promising zone adaptive sample size designs appear compelling in theory, but all simulated and practical evidence demonstrates that group sequential trials outperform these methods in terms of efficiency and power for confirmatory trials.

In this episode of "In the Interim…", Dr. Scott Berry examines the mathematical foundations and efficiency claims of the promising zone design for adaptive sample size in clinical trials.

Episode 30 of “In the Interim…” features Dr. Janet Wittes, Fellow of the American Statistical Association, past president of the Society of Clinical Trials, and founder of Statistics Collaborative, in discussion with Dr. Scott Berry.

Berry Consultants is excited to provide Part 3 of our RISW 2025 video series spotlighting our team members who will be presenting at the ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop (RISW) in Bethesda, MD, September 24–26, 2025.

Berry Consultants is pleased to announce a complimentary 10-part webinar series focused on simulation guided trial design using FACTS software to be held October through December 2025.

Berry Consultants is proud to provide Part 2 of our RISW 2025 video series highlighting our team members who will be presenting at the ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop (RISW) in Bethesda, MD, September 24–26, 2025.