Episode 28, “A Visit with Dr. Derek Angus”
Steroid use for community-acquired pneumonia and sepsis remains unsettled, with persistent inconsistencies in global evidence. Studies such as CAPE COD and APROCCHSS report mortality benefit, while larger international trials—ADRENAL and REMAP-CAP—report neutral or negative results.
In the latest "In the Interim…" episode, Dr. Derek Angus and Dr. Scott Berry parse differences in patient selection, dosing, and endpoints. They discuss persistent heterogeneity in treatment effects and propose learning healthcare systems with embedded randomization as a path forward.
Join the discussion on methodological reform and designing better trials for complex, high-stakes syndromes.
Listen to the full episode today: https://www.berryconsultants.com/resource/28-a-visit-with-dr-derek-angus