Podcast Episode
60: AI @ Berry
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Scott Berry, Ph.D.
President & Senior Statistical Scientist
In the 60th episode of "In the Interim…", Dr. Scott Berry, Dr. Nick Berry, and Dr. Joe Marion discuss how Berry Consultants uses AI in clinical trial design and software development.
In the 60th episode of “In the Interim…”, Dr. Scott Berry, Dr. Nick Berry, and Dr. Joe Marion discuss how Berry Consultants uses AI in clinical trial design and software development. The conversation addresses current applications, limitations, implications for productivity, and the ongoing need for human expertise in clinical trial design. The team examines both promising use cases and the risks associated with security, compliance, and AI-generated statistical work.
Key Highlights
AI is used to develop user interfaces and code modules, notably expediting tasks like R Shiny app development and software prototyping.
Statistical coding for complex modeling and simulation—such as numerical integration and predictive probability calculations—remains unreliable when delegated to AI and still requires direct oversight and manual review.
Attention to security and confidentiality is central; Berry prohibits the use of client-sensitive or patient data within AI tools.
Generative AI assists with drafting and editing documents, but the output tends to be non-specific, generic, and sometimes imprecise, requiring expert editorial input before use.
While embracing AI to improve efficiency, the discussion is critical of current AI hype, especially around black-box modeling and pushes back against the perception that current AI can replace domain-specific statistical design or strategic judgment.
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60: AI @ Berry
In the 60th episode of "In the Interim…", Dr. Scott Berry, Dr. Nick Berry, and Dr. Joe Marion discuss how Berry Consultants uses AI in clinical trial design and software development.
59: Drug Development and Sports: The 10-Run Rule and Futility
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58: ICH-E20, Regulators, and False Choices
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57: PANTHER: A Phase 2 International Platform Trial in ARDS
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56: A Visit with Byron Gajewski: KUMC, Innovative Trial Designs, the HOBIT Trial
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54: Making Sense of Hierarchical Composites
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53: The SNAP Trial with Professors Tong and Davis
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52: Bayesian Borrowing in Phase 3 Trials
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51: The Art of Storytelling with Shaun Cassidy
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50: The Fallacy of Ordinal Endpoints
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49: Mr. Berry Goes to Washington
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48: Platform Trial in Orthopaedic Surgery
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47: A Visit with Michael Harhay
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46: The FDA Bayesian Guidance
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45: Path 2 Parkinson's Prevention with Drs. Simuni and Wendelberger
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44: Statistical Communication
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43: The Rumor of One Trial for Substantial Evidence
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42: Communication for Scientists: A Discussion with Jenny Devenport
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41: Navigating the Arena: Platform Trials
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40: Jumping Hurdles: Interim Analyses for Funding Decisions
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39: Discussion with Kaspar Rufibach
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38: Bayesian Statistics in Clinical trials: The Past, Present, and Future
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37: A Visit with Stroke Neurologist Dr. Jeff Saver
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36: The Saga of the Lecanemab Adaptive Phase II Trial
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35: Teaching Statistics and Data Science through Sports
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34: Digital Googols
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33: A Visit with Andrew Thomson
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32: Moving Clinical Trial Goalposts
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31: The Not So Promising Zone Design
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30: A Visit with Dr. Janet Wittes
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29: Bayesian Clinical Trials with Frank Harrell
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28: A Visit with Dr. Derek Angus
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27: The Mystery of Clinical Trial Simulation
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26: Discussions on the ICH E20 Draft Guidance
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25: A Discussion with Michael Proschan on Response-Adaptive Randomization
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24: STEP Statistical Modeling
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22: The Time Machine
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21: The Legend of I-SPY 2 - Part B
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20: The Legend of I-SPY 2 - Part A
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19: The STEP Platform with Dr. Eva Mistry and Dr. Jordan Elm
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18: A Statistician Reads JAMA
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17: Seamless 2/3 Trial Designs
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16: Spending Alpha
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15: Prof Craig Ritchie: Looking Back at EPAD, Moving Forward in Alzheimer's Disease
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14: Drug Developers' Lessons from Sports: Regression-to-the-Mean
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13: DSMBs in Adaptive Trials with Roger Lewis
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12: Platform Trial in Psychiatry with Dr. Husseini Manji
In the latest episode of "In the Interim...", Dr. Scott Berry and Dr. Mike Krams sit down with Dr. Husseini Manji, to explore the potential of platform trials in advancing precision medicine within psychiatry, particularly in tackling complex mental illnesses.
11: Implementing Adaptive Trials
In Episode 11 of "In the Interim...", host Scott Berry discusses the nuances of implementing adaptive clinical trials with Dr. Anna McGlothlin and Dr. Michelle Detry from Berry Consultants.
10: Revisiting Seamless 2/3 Trial for GLP-1 Agonist
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9: I-SPY 2 to GBM AGILE and Beyond
In this episode of "In the Interim...," we sit down with Dr. Meredith Buxton to explore the evolution of platform trials from I-SPY 2 to GBM AGILE and Beyond.
8: External Data in Clinical Trials
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7: Remembering Jimmie Savage
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6: The Art and Slog of Innovating
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5: Religion, Politics, and Ordinal Outcomes
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4: HEALEY ALS Platform Trial with Dr. Merit Cudkowicz and Dr. Melanie Quintana
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3: FACTS 7.1 Release with Tom Parke
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2: When should you use adaptive design clinical trials?
In this episode of "In the Interim," we consider the nuances of adaptive design clinical trials with distinguished guests Dr. Scott Berry and Dr. Kert Viele from Berry Consultants. The conversation centers around the vital question: when should these adaptive designs be implemented?
1: The story of Berry Consultants
Discover the transformative journey of Berry Consultants, pioneers in adaptive clinical trials, and their impact on the future of medical research.