Berry logo
Innovative Trials
Adaptive Clinical TrialsBayesian ApproachPlatform Trials
Services
Trial DesignTrial ImplementationTherapeutic Areas
Software
Software
Software OverviewFACTSADDPLANQUOTES
More
About
About Us

Learn about our mission and values

Our Team

Meet the Berry team

Careers

Join our team

Contact Us

For more information or ask a question

Resources
Podcast

Clinical trial science thought leadership

Blog

Insights and updates from our experts

Publications

Authoritative research publications

FACTS Knowledge HUB

Clinical trial knowledge and technical guides

News and Events

Latest updates and trade shows

Webinars and Videos

Insights and updates from our experts

Useful Links

Handy links for quick access

View all resources

Latest podcast Episode

A podcast cover with "In the Interim...Thought leadership on statistical science and clinical trials.
13: DSMBs in Adaptive Trials with Roger Lewis
Go to episode
Contact Us
Videos
May 20, 2020
No items found.

Complete REMAP-CAP Video Library

Play video
Subscribe to In the Interim...

No items found.
https://remap-cap.org
Download PDF
View
This is some text inside of a div block.
Back to All Webinars and Videos

Other Webinars and Videos

View All Webinars and Videos

Berry Consultants SCT Meeting Preview

Multiple Berry Consultants team members will be presenting in a range of innovative clinical trial sessions at the upcoming Society of Clinical Trials (SCT) 46th Annual Meeting in Vancouver, British Columbia, Canada on May 18-21.
Read more
May 12, 2025

Why Simulate?

In this FACTS Webinar, Dr. Mike Krams of Berry Consultants hosts a panel of experts to discuss, “Why Simulate?”
Read more
April 15, 2025

JAMA Podcast Series: Evaluating Treatments for Amyotrophic Lateral Sclerosis

Author Sabrina Paganoni, MD, PhD, of Massachusetts General Hospital and Harvard Medical School, discusses results of the first 4 drug regimens from the HEALEY ALS platform trial and how this study design makes efficient use of resources.
Read more
February 17, 2025

President’s Council of Advisors on Science and Technology (PCAST)

Don Berry presents as part of a panel of Researchers on the topic of “Improving Scientific Reproducibility in an Age of International Competition and Big Data I” at the PCAST Public Meeting on January 31, 2014.
Read more
January 31, 2014

JAMA evidence Podcast Series: Bayesian Analysis, Using Prior Information

Roger J. Lewis, MD, PhD, discussed Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Melanie Quintana, PhD.
Read more
September 2, 2021

GBM AGILE Trial: How does GBM AGILE work?

Global Coalition for Adaptive Research released a series of Spotlight short videos presented by Don Berry on the GBM AGILE Trial.
Read more
August 11, 2021

JAMAevidence Podcast Series: Bayes for Clinicians Who Need to Know but Don’t Like Math with Dr. Anna McGlothlin

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
December 18, 2018

JAMAevidence Podcast Series: JAMA Guide to Statistics and Methods with Dr. Roger Lewis

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
December 5, 2019

JAMAevidence Podcast Series: Minimal Clinically Important Difference: Defining What Really Matters to Patients with Dr. Anna McGlothlin

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
August 6, 2020

JAMAevidence Podcast Series: Randomization in Clinical Trials with Dr. Roger Lewis

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
December 3, 2020

JAMAevidence Podcast Series: Logistic Regression: What It Is and How to Use It in Clinical Research with Dr. William Meurer and Dr. Juliana Tolles

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
January 7, 2021

JAMAevidence Podcast Series: Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Dr. Melanie Quintana

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
September 2, 2021

JAMAevidence Podcast Series: Time-to-Event Analysis with Dr. Juliana Tolles

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
March 3, 2023

JAMAevidence Podcast Series: Bayesian Hierarchical Models with Dr. Anna McGlothlin

This Podcast series by JAMA provides valuable interviews about the statistical and methodological foundations of clinical research.
Read more
July 3, 2024

SciPod Podcast Series: Innovative Clinical Trial Design Identifies Effective Drug and Its Most Efficacious Dose for Treating Early Alzheimer Disease

In this September 6, 2024 episode by SciPod Health and Medicine, SciPod summarizes the recent paper “Lecanemab for Patients with Early Alzheimer Disease: Bayesian Analysis of a Phase 2b Dose-Finding Randomized Clinical Trial” by Dr. Donald Berry (Founder of Berry Consultants) and Scott Berry (President of Berry Consultants).
Read more
September 6, 2024

Case Studies in using FACTS to design Clinical Trials: A 2-arm MACE safety study

Using FACTS to design a large 2-arm safety study, borrowing information from a previous trial, exploring alternative endpoints and using an enriched population.
Read more
November 21, 2024

Case Studies in using FACTS to design Clinical Trials: An Alzheimer’s Phase 2 dose finding study

A Phase 2 dose finding study using a Bayesian dose response model and response adaptive randomization across multiple doses and treatment regimens. Includes a presentation of the interim analyses from the actual trial that lead to the successful phase 3 trial of Lecanemab.
Read more
November 14, 2024

Case Studies in using FACTS to design Clinical Trials: A trial in hemorrhagic stroke with adaptive enrichment

A randomized two arm study, using a utility weighted modified Rankin score and rules for adapting the enrolment criteria based on the location of the haemorrhage.
Read more
November 7, 2024

Case Studies in using FACTS to design Clinical Trials: An open enrollment CRM dose escalation study

Designing a phase 1 dose escalation using Bayesian Logistic Regression Model (BLRM), with open enrolment (rather than cohort) using FACTS N-CRM.
Read more
October 31, 2024

Case Studies in using FACTS to design Clinical Trials: A two-arm study with adherence model driven effect size and irregular interim analyses

Using FACTS to design a two-arm study where differences in adherence between the arms drive the effect size. Uncertainty in the effect size prompted spacing the interims to correspond to different sample sizes resulting in irregular interim analyses. Using a uses a finite mixture model from previous data on the analysis endpoint to justify the irregular interims.
Read more
October 24, 2024

Case Studies in using FACTS to design Clinical Trials: A Seamless Phase 2/3 multiple endpoint diabetes trial

Is this the most complex and most successful trial ever designed and run? Looking at the AWARD 5 trial for what became Eli Lilly’s Trulicity drug. The drug used response adaptive randomization, longitudinal modelling, dose response modelling and a utility function combining 4 endpoints. The trial selected a successful dose and switched early from phase 2 to a successful phase 3.
Read more
October 17, 2024

The Biomarkers Consortium: I-SPY 2 Press Conference

Don Berry speaks as part of the press conference for I-SPY 2, an innovative breast cancer clinical trial.
Read more
March 17, 2020

Slowly but surely, Bayesian Ideas revolutionize medical research

Don Berry at the 2012 International Society for Bayesian Analysis (ISBA) World Meeting in Kyoto, Japan. https://videolectures.net/videos/isba2012_berry_bayesian_ideas
Read more
August 22, 2012

A Fully Bayesian World: What a Wonderful World

Scott Berry presents at the Royal Statistical Society’s, “PSI Debate: This house believes that pharmaceutical drug development and regulation should become fully Bayesian”.
Read more
October 26, 2012

The Design of Complex Adaptive Trials

Scott Berry presents at the “Transforming Drug Development – Delivering Innovation and Efficiency through Adaptive Clinical Trials” conference that was co-sponsored by Berry Consultants.
Read more
March 20, 2013

Introducing Decision-Making Under Uncertainty to Medical Research: Designing More Efficient and More Accurate Clinical Trials

Don Berry’s presentation at the Simons Institute for the Theory of Computing at University of California Berkeley.
Read more
September 19, 2016

Complete REMAP-CAP Video Library

https://remap-cap.org
Read more
May 20, 2020

Sit Down with Lindsay Berry

REMAP-CAP
Read more
August 21, 2021

Scott Berry – REMAP-CAP Current State Statistical Model

Scott Berry from Berry Consultants gives an overview of the current state statistical model for REMAP-CAP.
Read more
June 7, 2020

Complete PREPARE Video Library

PREPARE Webinar 07/04/2021 - Why future clinical trials will be platform trials
Read more
July 4, 2021

Why Future Clinical Trials will be Platform Trials (with Scott Berry at the 20:50 mark on “Taming the Beast”).

PREPARE Webinar 07/04/2021 - Why future clinical trials will be platform trials
Read more
July 4, 2021

HEALEY ALS Platform Trial Launch Announcement

Learn more about this groundbreaking trial designed by Berry Consultants to accelerate the development of effective treatments for people in ALS. Weekly updates and additional videos can be found on HEALEY ALS Platform Trial Video Library of Mass General Hospital.
Read more
August 30, 2020

The PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and Delivery

Dr. Ben Saville of Berry Consultants and Dr. Chris Butler of Oxford University present a Grand Rounds session on the PRINCIPLE Adaptive Platform Trial.
Read more
May 21, 2021

GBM AGILE Trial: Bringing Bayesian Statistics into Clinical Trials

Bringing Bayesian Statistics into Clinical Trials - Shortened Version
Read more
August 30, 2021

GBM AGILE Trial: What makes GBM AGILE an innovative trial?

What makes GBM AGILE an innovative trial?
Read more
August 11, 2021

GBM AGILE Trial: How is GBM AGILE paving the way for more innovative research?

How is GBM AGILE paving the way for more innovative research?
Read more
August 11, 2021

GBM AGILE Trial: A Brief History of GBM AGILE

Global Coalition for Adaptive Research released a series of Spotlight short videos presented by Don Berry on the GBM AGILE Trial.
Read more
July 21, 2021

Adaptive Platform Clinical Trials: Application to ILD

Roger J. Lewis, MD, PhD, lectured on REMAP-ILD at HCOR scientific meeting (Sao Paulo, Brazil).
Read more
March 29, 2023

The Implementation of Platform Trials for ALS Research

Dr. Melanie Quintana, statistical scientist and director at Berry Consultants, discussed innovative clinical trial design in ALS research at the 2023 MDA conference.
Read more
March 31, 2023

Introduction to Adaptive Trial Designs using FACTS: Platform Trials & MAMS designs

In this video we look at the different types of MAMS designs that includes Platform Trail designs. We look at the different design issues and analysis methods available for these sorts of trials. Originally aired November 9, 2023
Read more
November 9, 2023

Introduction to Adaptive Trial Designs using FACTS: Basket Trials

In this video we look at designing Phase 2 Basket Trials where a treatment is explored in a large number of sub-groups (too many to be able to suitably power the trial in each sub-group).
Read more
November 2, 2023

Introduction to Adaptive Trial Designs using FACTS: Seamless Phase 2/3 Trials

In this video we look at designing seamless phase 2/3 trials, where a multi-arm phase 2 transitions when it can, selecting a dose and transitioning to a confirmatory phase 3.
Read more
October 26, 2023

Introduction to Adaptive Trial Designs using FACTS: Phase 2 Arm Dropping and RAR

In this video we look at designing response adaptive randomization (RAR) and arm dropping multi-arm phase 2 trials.
Read more
October 19, 2023

Introduction to Adaptive Trial Designs using FACTS: Group Sequential Designs

In this video we look at designing Group Sequential trials for confirmatory phase 3 trials, where the trial includes interims to stop early for efficacy and futility.
Read more
October 12, 2023

Introduction to Adaptive Trial Designs using FACTS: Phase 1 Dose Escalation

In this video we look at the issues around designing Phase 1 Dose Escalation trials in oncology, where the aim is to explore increasing dose levels up to a limiting rate of toxicities.
Read more
October 5, 2023

FACTS Webinar: Response Adaptive Randomization RAR in multi arm trials aiming to select the best arm

This FACTS Webinar will address RAR: 1) A surprising amount of the literature considers just the two arm setting, when arguably the most interesting setting for this technique is the multi-arm one. 2) Present some results in favor of RAR. 3) Lastly there are still misconceptions around that RAR inflates type-1 error, where it is easy to show that the opposite can be true.
Read more
November 6, 2024

EU-PEARL Webinar - Non-Concurrent Controls in Platform Trials

Dr. Scott Berry and Dr. Kert Viele from Berry Consultants delivered a presentation during the EU-PEARL webinar on February 24.
Read more
February 24, 2022

Los Angeles County Predictive Modeling of the COVID-19 Pandemic

Berry Consultants released a video showcasing their support for the LA County Predictive Modeling for the COVID-19 Pandemic, which was recognized among the top achievements in quality and productivity by the County's Quality and Productivity Commission in 2021.
Read more
September 10, 2021

First Participants Enrolled in the Groundbreaking Trial Led by the Sean M. Healey & AMG Center for ALS at Mass Genera

The Sean M. Healey & AMG Center for ALS at Mass General has successfully enrolled its first participants in a pioneering clinical trial aimed at advancing ALS research.
Read more
August 3, 2020

Berry Consultants Webinar on SARS-COV-2 Vaccine Trials

On October 2, Berry Consultants hosted a public FACTS webinar led by Dr. Kert Viele, discussing the latest protocols and safety concerns of SARS-COV-2 vaccine trials from major pharmaceutical companies, with the recording available on their YouTube channel.
Read more
October 5, 2020

Berry Consultants Webinar on Designing Trials for COVID-19

On April 24, Berry Consultants hosted a public FACTS webinar on COVID-19 trials, featuring presentations from various experts, with recorded sessions and additional resources available on their YouTube channel and linked articles.
Read more
April 29, 2020

NHLBI ICTR Video released on Single Arm Trials

On October 29, 2018, Berry Consultants launched a video series featuring Dr. Anna McGlothlin discussing the benefits and challenges of single arm clinical trials, particularly in rare diseases, while encouraging viewers to explore additional resources on the ICTR website.
Read more
November 1, 2018

Berry Consultants Releases Videos on Adaptive Designs

Berry Consultants has launched three new videos on adaptive designs, featuring experts discussing topics such as DSMBs, biomarkers, and the intersection of NCAA football and the Ebola pandemic, adding to their previously released videos on related subjects, all available on their YouTube channel.
Read more
September 3, 2015
Berry logo
Join our newsletter
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Berry
HomeAboutOur TeamCareersContact Us
Innovative Trials
Adaptive Clinical TrialsBayesian ApproachPlatform Trials
Services
Trial DesignTrial ImplementationTherapeutic Areas
Software
Software OverviewFACTSADDPLANQUOTES
Resources
PodcastWebinars and VideosBlogPublicationsNews and EventsUseful Links
© 2025 Berry Consultants. All rights reserved.