Therapeutic Area
Neuroscience
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The Lancet Neurology
Neuroscience
Platform
Safety and efficacy of trehalose in amyotrophic lateral sclerosis (HEALEY ALS Platform Trial): an adaptive, phase 2/3, double-blind, randomised, placebo-controlled trial
June 1, 2025
DOI: 10.1016/S1474-4422(25)00173-5
Wiley Online Library
Neuroscience
Platform
Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial. Muscle Nerve.
May 26, 2025
DOI: 10.1002/mus.28442
The Lancet Neurology
Neuroscience
Dose Ranging
Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial
February 24, 2025
DOI: 10.1016/S1474-4422(24)00456-3
JAMA Neurology
Neuroscience
Platform
Verdiperstat in Amyotrophic Lateral Sclerosis Results From the Randomized HEALEY ALS Platform Trial
February 17, 2025
doi:10.1001/jamaneurol.2024.5249
JAMA
Neuroscience
Platform
CNM-Au8 in Amyotrophic Lateral Sclerosis The HEALEY ALS Platform Trial
February 17, 2025
doi:10.1001/jama.2024.27643
JAMA Network Open
Neuroscience
Platform
Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis A Randomized Clinical Trial
February 17, 2025
doi:10.1001/jamanetworkopen.2024.59058
JAMA
Neuroscience
Platform
Pridopidine in Amyotrophic Lateral Sclerosis The HEALEY ALS Platform Trial
February 17, 2025
doi:10.1001/jama.2024.26429
Stroke
Neuroscience
Stroke
Platform
Adaptive Platform Trials in Stroke
December 20, 2024
doi.org/10.1161/STROKEAHA.124.045754
American Heart Association Journal
Neuroscience
Stroke
Adaptive Clinical Trials in Stroke
October 22, 2024
DOI: 10.1161/STROKEAHA.124.046125
JAMA
Neuroscience
Enrichment
Writing Committee for the TESLA Investigators; Yoo AJ et al. Thrombectomy for Stroke With Large Infarct on Noncontrast CT: The TESLA Randomized Clinical Trial.
September 24, 2024
doi: 10.1001/jama.2024.13933
The New England Journal of Medicine
Neuroscience
Other
Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
September 5, 2024
doi: 10.1056/NEJMoa2314779.
The New England Journal of Medicine
Neuroscience
Enrichment
Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage
April 11, 2024
doi: 10.1056/NEJMoa2308440.