In this video we look at designing response adaptive randomization (RAR) and arm dropping multi-arm phase 2 trials.

Join Dr. Cora Allen-Savietta from Berry Consultants on October 25 for a presentation on a platform trial in Parkinson's disease.

Joe Marion's blog discusses the challenges of designing phase I dose-finding studies in oncology using the Continual Reassessment Method (CRM) and Bayesian approaches, emphasizing the importance of selecting appropriate prior distributions to balance patient safety and effective dose escalation, while suggesting that re-parameterizing models can simplify the design process.

In this video we look at designing Group Sequential trials for confirmatory phase 3 trials, where the trial includes interims to stop early for efficacy and futility.

In this video we look at the issues around designing Phase 1 Dose Escalation trials in oncology, where the aim is to explore increasing dose levels up to a limiting rate of toxicities.

On September 28, 2023, Kert Viele will moderate a panel at the ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop, discussing time trends in ongoing platform trials using real interim analyses from the PRINCIPLE and REMAP-CAP trials, focusing on their impact on clinical trial analyses, modeling adjustments, and the complexities of additive versus interactive time trends.